ZEB1 and colorectal carcinoma: In conclusion, we provided the first evidence that lncRNA XIST was overexpressed in CRC tissues, and lncRNA XIST upregulated the miR-200b-3p target gene ZEB1 by way of competitively ‘sponging’ miR-200b-3p, and then promoted cell proliferation, invasion, EMT and stem cell formation in vitro as well as tumorigenesis and metastasis in vivo (Figure 8).