For example, nuclear-enriched abundant transcript 1 can function as a diagnostic and prognostic biomarker in CRC;14 HOTAIR is a negative prognostic factor not only in primary tumors, but also in the blood of CRC.15 Zhang et al.16 found that lncRNA CASC11 can interact with hnRNP-K and activate the WNT/β-catenin pathway to promote growth and metastasis in CRC. This evidence concerns the gene HOTAIR and colorectal carcinoma.