PTEN and hepatocellular carcinoma: Furthermore, CLEC-2 was downregulated in liver cancer at both transcriptional and post-translational levels; this significantly related with upregulation of genes related with Akt signaling like GSK3 and eIF4E, with PTEN downregulation, with poorly differentiated histology (i.e., G4 in the Edmondson–Steiner classification), aggressive HCC phenotype bearing the transcriptomic signature and evidence of EMT.