GPC3 and hepatocellular carcinoma: Two of them (mir-15b-5p and mir-421) are involved in TGFβ1 pathway and in inflammatory signaling;26, 27 mir-15b-5p is also involved in G1-S transition.28 Mir-1303 modulates proliferation, migration and cell invasion and differentially controls Glypican-3 expression in HCC cells.29 Mir-221-3p is involved in cell cycle progression and has a oncogenic role in gastric carcinoma.30, 31 Mir-486-5p has a role in angiogenesis, lymphangiogenesis, and cell proliferation.32, 33 For some of these microRNAs, discordant indications on their role in HCC exist.