Results from a multicenter phase 2 clinical trial showed that metformin could yield objective PSA responses and induce disease stabilization for chemotherapy-naive CRPC.27 We found that combinatorial treatment of metformin and bicalutamide can additively repress the growth of prostate cancer.26 In this research, we demonstrated that metformin is capable of inhibiting enzalutamide-induced EMT in prostate cancer cells via repressing TGF-β1/STAT3 axis. The gene discussed is STAT3; the disease is Familial prostate cancer.