The specific points are listed as follows: (i) miR-323a-3p is frequently downregulated in BCa due to altered DNA methylation of IG-DMR, which indicates a poor overall survival rate of BCa; (ii) miR-323a-3p functions as a tumor suppressor to inhibit the EMT progression in BCa cells; (iii) MET and SMAD3 are identified as downstream target genes of miR-323a-3p; (iv) miR-323a-3p inhibits EMT in BCa cells by regulating MET/SMAD3/SNAIL circuit and (v) a mutual regulation may exist between MET and miR-323a-3p/miR-433/miR-409. The gene discussed is SMAD3; the disease is neoplasm.