The most widely used RDTs target histidine-rich protein 2 (HRP2), which is expressed by the Plasmodium falciparum (Pf) specific gene pfhrp2, with over 85% of RDTs tested in the WHO Foundation for Innovative New Diagnostics (FIND) Malaria RDT Evaluation Programme targeting PfHRP2 (World Health Organization, 2012a). This evidence concerns the gene HDGFL2 and malaria.