Furthermore, our analysis identified predicted target genes of DE miRNAs in PMECs at 3 hpc with E. coli that are enriched in top canonical pathways such as IL-10 signaling, PPAR signaling, NF-ĸB signaling, TNFR2 signaling, or arthritis-associated roles. The gene discussed is TNFRSF1B; the disease is Arthritis.