Due to recent progress in production of human embryonic stem cell-derived oligodendrocyte progenitor cells (hESC-OPCs) for ameliorating myelin diseasesuch as multiple sclerosis (MS) and the role of purinergic signaling in OPCs development, we avaluated the profile of purinergic receptors expression during developmentof OPCs from hESC. This evidence concerns the gene P2RX3 and multiple sclerosis.