On the other hand, in a recently reported case PET with 18F-PR04.MZ, a new high-affinity radiotracer for dopamine transporters, demonstrated significantly reduced binding of ligand within striatum and intact dopaminergic activity of the substantia nigra; reduction of tremor severity after levodopa was noted in this subject (Juri et al. 2015). The gene discussed is SLC6A3; the disease is Tremor.