Intestinal dysbiosis has also been demonstrated in SS patients, and, interestingly, gingival colonisation by Capnocytphaga ochracea in genetically predisposed subjects may lead to the activation of the adaptive immune system through the cross-reactivity against a von Willebrand factor type A domain protein (vWFA) that is produced by the microorganism and Ro-SSA self-antigens. The gene discussed is TRIM21; the disease is synovial sarcoma.