Disrupted gut tolerance of microbial agents may also be reflected by the detection of ANCAs in patients with inflammatory bowel diseases such as Crohn's disease, in whom (together with anti-glycoprotein 2, anti-granulocyte macrophage colony-stimulating factor, anti-Saccharomyces cerevisiae antibodies, and other antibody subsets) they represent a valid means of diagnosing and monitoring the course of the disease [57]. The gene discussed is GP2; the disease is inflammatory bowel disease.