NOD2 and infection: The activation of cells belonging to the innate immune system via the interactions of pathogen-associated molecular patterns (PAMPs) with Toll-like receptors (TLRs) or the nucleotide-binding oligomerization domain-containing protein 2 (NOD2) cascade, along with the subsequent production of IFNs, plays a key role in the clearance of infections sustained by Staphylococci, although it may contribute at the same time to the virulence of some strains of these microorganisms, like strain 502A [12].