Coit et al. investigated the oral microbiome of 31 BD patients and 15 controls by analysing salivary samples using high-throughput sequencing of the 16S rRNA V4 region [58] and found a reduced prevalence of Alloprevotella rava and increased colonisation by Haemophilus parainfluenzae, neither of which was significantly affected by concomitant immunosuppressive treatments (cyclosporine A, azathioprine, and prednisone) or genetic predisposition (HLA-B/MICA locus variants), but they were slightly restored by periodontitis treatment. This evidence concerns the gene HLA-B and Behcet disease.