Eremina et al. first reported that bevacizumab treatment in some cancer patients led to a renal pathology of glomerular endothelial swelling, red blood cell fragmentation, and intracapillary thrombi, which were characteristics of thrombotic microangiopathy, and subsequently reproduced these findings in podocyte-specific VEGF-A-deficient mice as above [44]. Here, VEGFA is linked to cancer.