VEGFA and wet macular degeneration: In multicenter, randomized, double-masked, controlled phase III clinical trials for the treatment of wet age-related macular degeneration, OPH1002 and OPH1003, tested the combined therapy of anti-PDGF (1.5 mg of pegpleranib, Fovista®) with anti-VEGF (ranibizumab), versus Lucentis monotherapy, found no improvement in vision at 12 months [18].