ESR1 and hereditary clear cell renal cell carcinoma: Similarly, the results for the three kidney-specific miRNAs, including fca- chrE3_33626-5p, which was validated by RT-PCR, showed significant enrichment for pathways that are relevant for kidney function, such as AMPK signaling, cell cycle checkpoint control, Estrogen receptor signaling, Renin-Angiotensin signaling and Renal cell carcinoma signaling (BH-adjusted P < 0.05).