The analysis of the seven miRNAs expressed in the brain tissues analyzed (i.e. brain stem, cerebellum and cerebral cortex) revealed significant enrichment for pathways that are specific or relevant for brain functions or diseases, including gap junction signaling, endothelin-1 signaling, ERK/MAPK signaling, GNRH signaling, p70S6K Signaling, CREB Signaling in Neurons, synaptic long term potentiation, glioma signaling (BH-adjusted P < 0.05). The gene discussed is CREB1; the disease is central nervous system cancer.