The miRNA miR-21-5p showed a repressive effect on the anti-apoptotic BCL2, but also on the proto-oncogenes TIAM1 (T-cell lymphoma invasion and metastasis 1) and MYC. Previous studies have reported that TIAM1 modulates a number of cellular processes associated with tumor progression and overexpression of this gene has been found in various tumor types38. This evidence concerns the gene BCL2 and neoplasm.