During liver diseases, members of the Tumor Necrosis Factor Superfamily (TNFSF), such as TNF-α, FasL (or Apo1/CD95) and TNF-Related Apoptosis Inducing Ligand (TRAIL) are expressed and released by immune cells, and can directly or indirectly trigger hepatocyte death4, 5. This evidence concerns the gene TNFSF10 and liver disorder.