FOXO3 and chronic kidney disease: To investigate the anti-muscle atrophy effect of JPYS decoction and its possible mechanism, in the present study, 5/6nephrectomy-induced CKD rats were performed, and results have shown that JPYS decoction considerably prevented body weight loss, muscle mass loss, muscle fiber size decrease, and muscle protein proteolysis, along with inhibition of UPS and FoxO3a.