INS and hydrops fetalis: As shown in Fig. 1c, fasting insulin concentrations significantly increased irrespective of genotypes (repeated measures ANOVA, pAA/AG = 0.038 and pGG = 0.039; interaction term rs4343 (recessive model × HF intervention: p = 0.175), with significant differences in response to 1 week of HF diet (Bonferroni posthoc analysis pAA/AG = 0.008 and pGG = 0.005).