During HF diet intervention (Table 2), fasting glucose values and glucose tolerance as assessed by ivGTT did not change, whereas fasting insulin values (repeated measures ANOVA; p = 0.006) and HOMA-IR increased (repeated measures ANOVA; p = 0.012) with significant differences in response to 1 week of HF diet (Bonferroni posthoc analysis; LF6 (clinical investigation day (CID) after 6 weeks of carbohydrate-rich low-fat diet) vs. HF1 (CID after 1 week of high fat diet): pfasting insulin = 2.4 × 10−4, pHOMA-IR = 0.002). The gene discussed is INS; the disease is hydrops fetalis.