Univariate and multivariate Cox proportional hazards analyses were performed on the cohort of 450 MM patients who received comparable treatment to determine the relative prognostic values of the 201 couples combining unobserved nodes and all signs (+, −, 0) and the three strongest known prognostic variables in MM (Table 3); these were the translocation of chromosomes 4 and 14 (t(4;14)), the deletion in the short arm of chromosome 17 (del(17p)) and serum 2-microglobulin ≥5.5 mg/L (β2-microglobulin) for OS determination51. The gene discussed is HLA-G; the disease is Miyoshi myopathy.