As non-HDL-C represents the full components of atherogenic lipids (LDL-C, very-low-density lipoprotein [VLDL], intermediate-density lipoprotein [IDL], and lipoprotein[a]) and is a surrogate marker for apolipoprotein B (Apo B) for routine clinical practice17, it has recently been gaining importance over LDL-C as cardiovascular risk marker in patients with ASCVD. The gene discussed is APOB; the disease is atherosclerosis.