CD40LG and infection: Three individuals, AS1, AS2, and AS5, with an EBV antibody profile equivalent to that seen in patients during the acute phase of IM (anti-VCA IgM+, anti-VCA IgG+ or IgG−, anti-EBNA1 IgG−) had circulating EBV genome loads well within the range of those in patients during the acute phase of IM, whereas a fourth individual, AS6 (anti-VCA IgM+, anti-VCA IgG+, anti-EBNA1 IgG−), had a relatively low load, although it may be that we had missed an earlier peak of infection in this particular case.