SYP and neoplasm: We followed up on this potential insight by assessing the extent of neuroendocrine differentiation of our case by utilizing the standard, routine IHC stains commonly used in the anatomic pathology laboratory for this purpose: synaptophysin and chromogranin A. We found the patient's tumor had focal to patchy staining of both markers, indicating some partial neuroendocrine differentiation, similar to the NCI-H716 cell line.