TRH and Anterior hypopituitarism: Therefore, our patient’s anterior hypopituitarism was probably due to a combination of impaired pituitary somatotroph, thyrotroph, and gonadotroph, and diminished delivery of endogenous hypothalamic GRF, TRH, LHRH, and CRH to the anterior pituitary, which resulted from both increased intrasellar pressure, and mechanical compression of portal vessels and the hypophyseal stalk.