FMR1 and fragile X-associated tremor/ataxia syndrome: Besides conferring familial risk, the FMR1 premutation is associated with its own clinical consequences, which include increased risk for mental health disorders [4], mild cognitive deficits [5], and physical health complications such as fragile X-associated premature ovarian insufficiency and fragile X-associated tremor ataxia syndrome (FXTAS; [6, 7]).