SAA1 and amyloidosis: The amyloidoses represent a group of disorders in which insoluble proteins deposit in tissues, resulting in damage to involved organs.[1] Secondary (AA) amyloidosis is one of the most common forms of amyloid diseases.[2] The amyloidogenic protein, AA type amyloid fibrils, is a proteolytic fragment of serum amyloid A protein (SAA), which is produced by the liver as an acute phase reactant.