Carbocyclic 7‐bromo‐7‐deazapurine nucleoside 47 is a subnanomolar inhibitor of ADK (IC50 = 0.47 nM against human ADK) which showed antinociceptive activity in animal acute, inflammatory, and neuropathic pain models (Fig. 13).99 The gene discussed is ADK; the disease is neuropathic pain.