The folate hydrolase 1 (FOLH1) C484T (rs202676) polymorphism may influence the binding potential of FOLH1.7 Dietary folates (but, notably, not FA) must be hydrolyzed by FOLH1 before they can be absorbed.8 Despite not directly influencing FA uptake, the FOLH1 C484T genotype has been implicated in the beneficial effect of FA on negative symptoms in patients with schizophrenia (Roffman et al., 2013). This evidence concerns the gene FOLH1 and schizophrenia.