In the total analyses, the combined results revealed that the G variant of the PADI4 -92C/G gene polymorphism was significantly associated with an increased risk of RA in the Chinese population (for G vs C: OR=1.32, 95%CI=1.02–1.71; for GG+CG vs CC: OR=1.75, 95%CI=1.20–2.53; Figure 2; Table 2). This evidence concerns the gene PADI4 and rheumatoid arthritis.