AGBL2 and open-angle glaucoma: Tham et al.[28] also reported that a higher GRS derived from the 7 IOP-related genetic variants near TMCO1, CAV2, GAS7, ABCA1, FNDC3B, ABO, and PTPRJ/AGBL2 (ATP/GTP binding protein like 2) was significantly associated with a greater risk of POAG.