Scheetz et al.[38] reported that non-Hispanic white OH patients with TMCO1 risk alleles participating in the Ocular Hypertension Treatment Study had a 12% higher cumulative frequency of glaucoma developing than OH patients with no TMCO1 risk alleles, suggesting a difference in the genetic background between the patients with OH and HTG, although the TMCO1 genetic variants are not non-IOP-related but IOP-related genetic variants. The gene discussed is TMCO1; the disease is glaucoma.