SREBF1 and neoplasm: Next, we assessed expression of genes involved in the adipogenic transcription cascade including the upstream genes sterol regulatory element binding protein (SREBP)-1c, C/EBPβ and C/EBPδ, as well as the downstream genes C/EBPα and PPARγ in the gastrocnemius muscle of rats on the control diet to identify a potential mechanism for skeletal muscle fat accumulation in response to the tumor-bearing state before and during chemotherapy treatment.