While expression of SREBP-1c and C/EBPβ were not altered (S1 Fig), C/EBPδ displayed a significant increase in response to the tumor-bearing state (p<0.001) and after each cycle of chemotherapy (cycle-1, p<0.05; cycle-2, p<0.001) in animals on the control diet compared with reference animals (Fig 4A). This evidence concerns the gene SREBF1 and neoplasm.