When combined, the global proteome analyses led to the identification of 2,526 proteins, including 12 proteins encoded by well-confirmed AD loci (APP, APOE, PSEN2, CLU, PICALM, BIN1, PTK2B, RIN3, ZCWPW1, FERMT2, ABI3, and TREM2). The gene discussed is PICALM; the disease is Alzheimer disease.