TCF4 and Fuchs endothelial corneal dystrophy: In 2010, Baratz and colleagues [18], through a genome-wide association study (GWAS) in white American cases, reported a highly significant association between single nucleotide polymorphisms (SNPs) in the TCF4 (Transcription factor 4) gene and late-onset FECD; the intronic SNP rs613872 was the most significantly associated variant.