Furthermore, the triple negative model showed significantly reduced number and area of metastases after HBOT with a reduction in the EMT markers, N-cadherin, Axl and collagen type I. Thus, as hypoxia is a negative prognostic factor for breast cancer patients, hyperoxia may provide a favourable adjuvant therapeutic approach for breast cancer growth and progression which should be evaluated further. This evidence concerns the gene CDH2 and breast carcinoma.