Considering budesonide could attenuate the release and expression of IL-6 and IL-8 in bronchial epithelial cells[22] and block the release of cytokines and MMPs in COPD lung fibroblasts[23], it’s plausible that Bud/Form reduced systemic inflammation through attenuating airway and pulmonary inflammation in COPD. The gene discussed is IL6; the disease is chronic obstructive pulmonary disease.