This is the first randomized (not double blinded) clinical trial to compare the effects of Tio and/or Bud/Form on systemic inflammation in stable COPD patients of group D. The study showed that a long-term treatment with Bud/Form alone or with Tio reduced circulating CRP levels in COPD patients of group D, while treatment with Tio alone did not. The gene discussed is CRP; the disease is chronic obstructive pulmonary disease.