Glutamine supplementation has been shown to regulate NF-κB and phosphoinositide-3-kinases (PI3K)-protein kinase B (Akt) signaling in vivo in a DSS-induced colitis model [12] and to enhance heat shock protein (HSP) expression both in vitro and in vivo in an experimental colitis models [15]. The gene discussed is AKT1; the disease is colitis.