CCN2 and esophageal squamous cell carcinoma: Han et al. reported that miR-145 could bind with the 3′UTR of connective tissue growth factor (CTGF) in dual luciferase reporter gene assay, and up-regulation of miR-145 or down-regulation of CTGF could suppress the proliferation, migration, invasion and EMT process of ESCC ECA109 cells [8].