miR-145 is significantly down-regulated in ESCC tissues and cell lines compared with normal tissues and cell lines [4,5,6,7], and up-regulation of miR-145 can significantly suppress proliferation, migration, and invasion as well as epithelial–mesenchymal transition (EMT) of ESCC cells by targeting connective tissue growth factor (CTGF) [8]. Here, CCN2 is linked to esophageal squamous cell carcinoma.