PLAU and keratitis: Furthermore, leukocyte infiltration into the cornea associated with LPS-induced keratitis was found to be restrained in mice deficient in urokinase-type plasminogen activator (uPA) compared with wild-type mice, and the LPS-induced production of both chemokines and MMP-9 was attenuated in corneal fibroblasts from the u-PA-deficient mice compared with those from wild-type mice.