αvβ6, originally identified on airway epithelial cells, and as a fibronectin receptor on colon carcinoma cells, was shown in a landmark study to be a local activator of latent TGFβ, and lack of αvβ6 in mice startlingly phenocopied the TGFβ1 knock-out mouse [38] (see Introduction). Here, TGFB1 is linked to colon carcinoma.