BDNF and Cognitive impairment: 2015; Asadbegi et al. 2017) and synaptic plasticity (Karimi et al. 2015; Asadbegi et al. 2016). Moreover, a recent investigation supported the link between high fat intake and cognitive impairment by revealing that HFD reduces hippocampal BDNF, neuronal plasticity and learning in rats (Molteni et al. 2002; Zhang et al. 2005). Accordingly, saturated fat, hydrogenated fat, and cholesterol can profoundly impair memory and hippocampal morphology (Granholm et al. 2008).