The absence of a(n) (detectable) effect of BRCA2 dysfunction on ovarian reserve in most studies may be the result of a true lack of a difference, of insufficient power, and/or of either a later-in-life-occurring or more subtle decline in ovarian reserve, corresponding to the lower risk and higher age at diagnosis of breast and ovarian cancer associated with BRCA2 mutations [33]. The gene discussed is BRCA2; the disease is ovarian cancer.