In addition, in response to H2O2 or cisplatin treatment, as UBC12 deletion reduced cell sensitivity while UBC12 re-expression reduced cell survival (Fig. 7B and 7C), it is possible that enhanced NEDDylation of PCNA could reduce TLS activity and the sensitivity of tumor cells to cisplatin treatment, which needs further study in the future. The gene discussed is PCNA; the disease is neoplasm.