CYP2D6 and cancer: In Koreans with MBC, CYP2D6*10/*10 genetic polymorphisms have been associated with reduced plasma concentrations of the tamoxifen active metabolites endoxifen and 4-hydroxytamoxifen, as well as reduced clinical benefit (complete response, partial response, or stable disease ≥ 24 weeks) and significantly shorter median time to progression (P = .0032).24 These racial variations highlight the importance of evaluating the efficacy and safety of cancer medications within the Asian population.