GNRH1 and cancer: Table 2 shows the enriched KEGG pathways for the 100 representative genes for DIM. Three pathways including pathways in cancer, MAPK signaling pathway, and GnRH signaling pathway were enriched. It was reported that the transforming growth factor-beta (TGF-β) superfamily includes a variety of cytokines expressed in the skeletal muscle. Members of this superfamily that are of great importance in the skeletal muscle are TGF-β1, mitogen-activated protein kinases (MAPKs), and myostatin [20].