Infiltrating eosinophils further drive EoE inflammation via a multitude of mechanisms including degranulation, inflammatory, and profibrotic cytokine secretion such as IL-4, IL-5, IL-13, GM-CSF, and TGFβ1, and eosinophil extracellular trap formation, which correlates with inflammatory features such as white exudates in active EoE (40, 69). The gene discussed is CSF2; the disease is eosinophilic esophagitis.