AGO2 and infection: Based on our in vitro results that the highest level of hAgo2 occurs at 0% to 1.5% parasitemia but decreased when the parasitemia was higher, hAgo2 must translocate via MPs into the parasites either at the beginning of the infection or when the extent of infection is mild; however, hAgo2 is consumed if the parasite growth is not controlled, and it invades more RBCs.