AKT1 and colorectal cancer: Previously, Huang et al. found that TMSB4X overexpression in colorectal cancer may promote tumor progression by inducing an EMT via activation of integrin-linked kinase (ILK) and consequentially its signal transduction through phosphorylation of Akt, glycogen synthase kinase 3 (GSK3) and beta-Catenin19, 39.