IFNA1 and cryohydrocytosis: Metformin could reduce the levels of circulating insulin41–44 and aid in improving responses to antiviral treatment, including a combination of pegylated IFN alpha-2a (PEG-IFNα-2a) and ribavirin (RBV), in patients with CHC of the naïve genotype 1 (G1) subtype45.