In addition, knockdown of Nm23-H1 also altered the polymerization of actin and increased the protein levels of EMT-related proteins, fibronectin, N-cadherin, vimentin, phospho-FAK and vinculin (Fig. 5B), implying that a decrease in Nm23-H1 increases the invasive ability of lung cancer cells. This evidence concerns the gene CDH2 and lung cancer.