SP1 and lung carcinoma: In this study, we demonstrated a new molecular mechanism by which Nm23-H1 can affect lung cancer progression, wherein Nm23-H1 increases Sp1 expression during lung cancer progression by affecting the IRES-mediated translational activity through stabilizing the protein stability of hnRNPA2/B1; these functions imply that Nm23-H1 upregulation in the early stages of lung cancer and downregulation in the late stages of lung cancer might contribute to the Sp1 level during lung cancer progression.