We will focus on to functionally characterize and validate the C allele of FZD4-miR-SNP, rs713065, in the miR-204 binding site in the FZD4 3′UTR, which was shown to be associated with a less aggressive NSCLC phenotype30 and to determine the biological and clinical relevance of this novel epidemiological FZD4-miR-SNP biomarker in NSCLC cell lines, preclinical mouse models, and in clinical plasma and tissue samples. This evidence concerns the gene FZD4 and non-small cell lung carcinoma.