FZD4 and lung adenocarcinoma: Similarly, a down-regulated expression of miR-204 was also detected in a panel of ~40 NSCLC cell lines compared to that of normal human bronchial epithelial (HBEC) cells (see Supplementary Fig. S5A) and a reciprocal correlation between miR-204 and FZD4 gene expression was displayed in primary lung adenocarcinoma (LUAD) and squamous carcinoma (LUSC) tumors from The Cancer Genome Atlas (TCGA) database (see Supplementary Fig. S5B).