Our findings suggest that the novel epidemiological miR-SNP (rs713065) loci in the 3′UTR of FZD4 may significantly influence overall survival in early stage NSCLC patients by specifically and differentially interacting with miRNAs such as miR-204, modulating FZD4 expression and cellular function in the Wnt/FZD4-signaling driven tumor cell proliferation and progression pathways thus identifying novel therapeutic targets and treatment strategies for NSCLC. Here, FZD4 is linked to non-small cell lung carcinoma.