To determine whether prostate cancer cells reduce stromelysin expression during cancer progression similar to stromal fibroblasts, we collected the CM of the androgen-responsive LNCaP lineage (LNCaP and C4-2) and androgen-insensitive PC3 lineage (PC3 and PC3M) prostate cancer cell lines and measured MMP-3 and -10 concentrations. The gene discussed is MMP3; the disease is prostate cancer.