MMP3 and Familial prostate cancer: To determine whether the upregulation of MMP-3 in prostate cancer cells by hydrogen peroxide is linked to miRNA-mediated posttranscriptional regulation, we first focused on miR-888, miR-6800, and miR-371, which were predicted to be mmp-3-targeting miRNAs by two algorithms (miRNA.org and TargetScan).