When BRCA1 and BRCA2 tumors in both data sets were combined, despite differences in sequencing platform, both ovarian and breast tumors associated with germline BRCA1 and BRCA2 mutations without locus-specific LOH had significantly lower HRD-Mean scores compared to ovarian and breast tumors with locus-specific LOH (P < 0.0005) (Fig. 2f). Here, BRCA1 is linked to breast neoplasm.