Three of 23 (13%) breast and three of 15 (20%) ovarian tumors associated with BRCA1 germline mutations, and seven of 16 (44%) breast and one of six (17%) ovarian tumors associated with BRCA2 germline mutations did not have BRCA locus-specific LOH (Fig. 1, Supplementary Data 3, Supplementary Table 2). This evidence concerns the gene BRCA1 and ovarian neoplasm.