In the glioma tissues, miR-29c expression was down-regulated, whereas SP1 and MGMT mRNA expression was up-regulated; moreover, XIST was inversely correlated with miR-29c, whereas positively correlated with SP1 and MGMT expression in glioma tissues, indicating that targetting XIST to rescue miR-29c expression, thereby inhibiting the chemoresistance of glioma cells to TMZ may be a promising strategy for improving the efficiency of TMZ-based chemotherapy. Here, SP1 is linked to central nervous system cancer.